The ATF4 transcription factor network plays a critical role in controlling the shift from pro-survival to pro-apoptosis regimes when mammalian cells experience starvation, viral infection, ER or oxidative stresses. Continued activation of pro-survival pathways with failure to initiate apoptosis under chronic stress is associated with dysfunction of the ATF4 network and is a feature of cells undergoing tumorigenesis. The shift between the pro-survival and pro-apoptosis regimes is observed to be switch-like over time but the mechanisms by which this shift occurs, or which components contribute to this emergent behaviour, are not fully understood. It may be possible to gain a better understanding of the factors that control this network by studying it in contextually isolated modules identifying unique dynamical motifs that may contribute to the ATF4 network's emergent dynamical behaviour. Self-limiting ATF4 regulation has been observed with respect to CARE (C/EBP-ATF Response Element)-containing targets under amino acid limitation and describes behaviour in which the expression of these targets is initially promoted and then later repressed by other targets in a timed program. A model of ATF4's regulation of Cat-1, an amino-acid transporter that is upregulated in response to amino-acid starvation, is evaluated as a potential example of a self-limiting motif.
Wednesday, June 16 at 03:15pm (PDT)Wednesday, June 16 at 11:15pm (BST)Thursday, June 17 07:15am (KST)
CDEV CDEV-24 (Session: PS04)
"The Dynamics of Vesicles Driven Through Closed Constrictions by Molecular Motors"
CDEV CDEV-25 (Session: PS04)
North Carolina State University
"Contraction and Connectivity in Simulated Cytoskeletal Networks"
CDEV CDEV-28 (Session: PS04)
Department of Biology, Geology and Environmental Sciences and Department of Mathematics and Statistics, Cleveland State University
"Modeling Chromosome Dynamics During Prophase I of Meiosis"
CDEV CDEV-29 (Session: PS04)
"Diffusion on Dynamical Networks with Applications to Cell Biology"
IMMU IMMU-10 (Session: PS04)
Texas Christian University
"Incorporating Symptom Scores into Viral Kinetic Models"
IMMU IMMU-11 (Session: PS04)
San Diego State University
"Modeling the risk of HIV infection for drug abusers"
IMMU IMMU-7 (Session: PS04)
"Mathematical models of Usutu virus infection"
IMMU IMMU-9 (Session: PS04)
Hauptman-Woodward Medical Research Institute
"Computational geometry, Delaunay tessellations and alpha shapes for protein interactions: Exploring Coronavirus Mpro drug binding"
MEPI MEPI-47 (Session: PS04)
St. Olaf College
"Modeling Public Health Impact of E-Cigarettes on Adolescents and Adults"
MEPI MEPI-48 (Session: PS04)
Benjamin Adam Catching
"Examining face-mask usage as an effective strategy to control COVID-19 spread"
MEPI MEPI-52 (Session: PS04)
Pedro Henrique Pinheiro Cintra
Gleb Wataghin Institute of Physics, University of Campinas
"Evaluating the effect of non pharmaceutical interventions on COVID-19 infection dynamics through agent based models"
MEPI MEPI-54 (Session: PS04)
University of Alberta
"A spatio-temporal model for the spread of chronic wasting disease"
MEPI MEPI-55 (Session: PS04)
João Pedro Valeriano Miranda
Institute for Theoretical Physics, State University of São Paulo, São Paulo, Brazil
"Memory effect in time-window epidemic curve forecasting using Approximate Bayesian Computation"
ONCO ONCO-22 (Session: PS04)
"Enhancing CAR-T Immunotherapy to Attack Both Tumor and Cancer Stem Cells"
ONCO ONCO-25 (Session: PS04)
University of British Columbia
"A new inter-cluster similarity measure for high-dimensional data can facilitate analysis of heterogeneous mass-cytometry data"
ONCO ONCO-26 (Session: PS04)
Department of Computational and Quantitative Medicine, Division of Mathematical Oncology, Beckman Research Institute, City of Hope National Medical Center
"Destabilization of CAR T-cell treatment efficacy in the presence of dexamethasone"
ONCO ONCO-30 (Session: PS04)
University of Minnesota Duluth
"Simulating Heterogeneity in Deterministic Models of Prostate Cancer Response to Immunotherapy with Standing Variations Modeling"
ONCO ONCO-31 (Session: PS04)
"A multiscale model for tumoral vascular growth: blood flow and cell dynamics"
OTHE OTHE-10 (Session: PS04)
Clarkson University, NY
"Modeling the homeostatic length of the rod outer segment in zerbrafish"
OTHE OTHE-12 (Session: PS04)
Department of Mathematics, University of California, Riverside
"Multi-scale computational model for understanding the mechanisms controlling tissue shape and structure in the shoot apical meristem of Arabidopsis thaliana"
OTHE OTHE-13 (Session: PS04)
"Novel Operon Dynamics in the Presence of State-Dependent Delays"