Photoreceptors are the sensory cells of the eye, which perform the most essential role in vision. There are two types of photoreceptors: rods for night and peripheral vision and cones for color vision. Glucose is the main fuel for photoreceptors, and they break it down to form lactate, lipids and other metabolites needed to create energy and to renew the light-absorbing outer segments, which are periodically shed. Thus, properly functioning metabolic processes ensure the structural integrity and vitality of photoreceptors. The progression of degenerative retinal diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP) has been linked to nutrient deprivation. We analyzed a mathematical model for the metabolic dynamics of a cone photoreceptor via bifurcation analysis and time-varying global sensitivity analysis (GSA) in order to identify factors that increase the risk of cone degeneration in AMD and RP when glucose supply to photoreceptors is low. Our results indicate that the factors of greatest importance include glucose availability and transport, utilization of lipids for photoreceptor outer segment renewal and -oxidation of fatty acids to provide auxiliary metabolites for energy production. In addition, the GSA helped to uncover insights into timing of intervention strategies to rescue the cone cell.
Thursday, June 17 at 11:30am (PDT)Thursday, June 17 at 07:30pm (BST)Friday, June 18 03:30am (KST)
MS20-CBBS: WiMB: Mathematical modeling and its application
Organized by: Qimin Huang (Case Western Reserve University, USA), Katie Storey (University of Michigan, USA)
- Atanaska Dobreva (Arizona State University, USA) "Investigating pathological mechanisms in cone photoreceptor vitality and the timing of rescue strategies via bifurcation analysis and time-varying sensitivity analysis"
- Katie Storey (University of Michigan, USA) "A Framework for Performing Data-Driven Modeling of Tumor Growth with Radiotherapy Treatment"
- Qimin Huang (Case Western Reserve University, USA) "Investigating the impact of combination phage and antibiotic therapy: A modeling study"
- Hwayeon Ryu (Elon University, USA) "Bifurcation and sensitivity analysis reveal key drivers of multistability in a model of macrophage polarization"
MS20-CDEV: Dynamics and networks in single-cell biology
Organized by: Adam Maclean (Univeristy of Southern California) & Russell Rockne (City of Hope, USA) Note: this minisymposia has multiple sessions. The second session is MS19-CDEV.
- Amy Brock (University of Texas at Austin, USA) "Clonally-resolved mapping of cancer cell trajectories under therapeutic pressure"
- Meghan Ferrall-Fairbanks (University of Florida, USA) "Single-cell eco-evolutionary dynamics of intratumor heterogeneity"
- Stephen Williams (10X Genomics, USA) "Analyzing spatial and high-resolution single cell multi-omic data"
- Sihem Cheloufi (University of California, Riverside, USA) "Mathematical modeling of chromatin accessibility to predict stem cell plasticity"
MS20-DDMB: Data-Driven Modeling and Analysis in Mathematical Biology
Organized by: Tomas Carino-Bazan (University of California, Santa Barbara, United States), Daniel Wilson (Boston University, United States) Note: this minisymposia has multiple sessions. The second session is MS19-DDMB.
- Daniel Wilson (Boston University, United States) "Inferring the molecular reach of antibodies from antigen binding data using an agent-based spatial model"
- Paul Atzberger (University of California, Santa Barbara, United States) "Variational Autoencoders with Manifold Latent Spaces for Learning Nonlinear Dynamics"
- Guy Wolf (Université de Montréal; Mila - Quebec AI Institute, Canada) "Multiscale exploration of single cell data with geometric harmonic analysis"
- John Lagergren (Oak Ridge National Laboratory, United States) "Data-driven network analysis detects longitudinal environmental changes with impacts on food, energy, and pandemics"
MS20-ECOP: Population Dynamics Across Interacting Networks or Scales
Organized by: Necibe Tuncer (Florida Atlantic University, USA), Hayriye Gulbudak ( University of Louisiana at Lafayette, USA), Cameron Browne (University of Louisiana at Lafayette, USA) Note: this minisymposia has multiple sessions. The second session is MS19-ECOP.
- Maia Martcheva (University of Florida, USA) "A Network Immuno-epidemiological Model of HIV and Opioid Epidemics"
- Stanca M. Ciupe (Virginia Tech, USA) "Neutrophil dynamics and their role in disease: a multi-scale investigation"
- Michael Cortez (Florida State University, USA) "Using sensitivity analysis to explore the context dependent relationships between host species richness and disease prevalence"
- Juan B. Gutiérrez (University of Texas at San Antonio, USA) "Data, reality, and cognitive dissonance. On modeling what we don’t see with data we don’t have."
MS20-EVOP: Evolutionary Theory of Disease
Organized by: Jesse Kreger (University of California, Irvine, United States), Natalia Komarova (University of California, Irvine, United States) Note: this minisymposia has multiple sessions. The second session is MS19-EVOP.
- Chadi M. Saad-Roy (Princeton University, United States) "The evolution of an asymptomatic infectious stage: analysis of a simple evolutionary-epidemiological model"
- Jasmine Foo (University of Minnesota, United States) "Power law transitions in site frequency spectra of neutrally evolving tumors"
- Mohammad Kohandel (University of Waterloo, Canada) "Predicting mutability of the genomic segments of a pathogen"
- Alison Hill (Johns Hopkins University, Institute for Computational Medicine, United States) "Selection for SARS-CoV-2 variants at the within-host and population scale"
MS20-IMMU: The pressing need for within-host models of the pulmonary immune response
Organized by: Luis Sordo Vieira (Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, United States), Marissa Renardy (University of Michigan/Applied BioMath, United States), Tracy Stepien (Department of Mathematics, University of Florida, United States) Note: this minisymposia has multiple sessions. The second session is MS19-IMMU.
- Julie Leonard-Duke (University of Virginia/Robert M. Berne Cardiovascular Research Center, United States) "Computational Modeling of Fibroblast Subpopulations in Idiopathic Pulmonary Fibrosis"
- Amber M. Smith (University of Tennessee Health Science Center, USA) "Bacterial coinfections: from influenza to SARS-CoV-2"
- Elsje Pienaar (Purdue University, United States) "Mycobacterium avium infection in the lungs: and agent-based model exploring early infection events"
- Angela Reynolds (Virginia Commonwealth University, United States) " Mathematical modeling of lung inflammation from insult to recovery"
MS20-MEPI: Models of COVID-19 Vaccination, Non-Pharmaceutical Interventions, and Relaxation
Organized by: Jane Heffernan (York University, Canada), Miranda Teboh Ewungkem (Lehigh University, USA), Zhilan Feng (Purdue University, USA), John Glasser (Centres for Disease Control, USA) Note: this minisymposia has multiple sessions. The second session is MS11-MEPI. The third session is MS16-MEPI.
- Melanie Prague (University of Bordeaux, France) "Multi-level modeling of COVID-19 epidemic dynamics in French regions, estimating the combined effects of multiple non-pharmaceutical interventions"
- Gerardo Chowell (Georgia State University, USA) "Ensemble modeling approaches for forecasting infectious disease spread"
- Iain Moyles (York University, Canada) "Cost and Social Distancing Dynamics in a Mathematical Model of COVID-19"
- Seyed Moghadas (York University, Canada) "Effectiveness of COVID-19 Vaccines in the Context of Emerging Variants"
MS20-MFBM: Algebra, Combinatorics, and Topology in Modern Biology
Organized by: Daniel Cruz (Georgia Institute of Technology, U.S.), Margherita Maria Ferrari (University of South Florida, U.S.) Note: this minisymposia has multiple sessions. The second session is MS19-MFBM.
- Mustafa Hajij (Santa Clara University, U.S.) "TDA-Net: Fusion of Persistent Homology and Deep Learning Features for COVID-19 Detection in Chest X-Ray Images"
- Hector Banos (Dalhousie University, Canada) "Identifiability of Species Network Topologies from Genomic Sequences"
- Nida Obatake (Texas A&M University, U.S.) "Mixed Volume of Chemical Reaction Networks"
- Raina Robeva (Randolph-Macon College, U.S.) "Algebraic Biology in the Curriculum"
MS20-MMPB: Deterministic and stochastic models for complex cardiovascular phenomena
Organized by: Martina Bukac (University of Notre Dame, United States), Daniele Schiavazzi (University of Notre Dame, United States) Note: this minisymposia has multiple sessions. The second session is MS14-MMPB.
- Mitchel Colebank (North Carolina State University, United States) "Modeling and simulation of fluid dynamics in chronic thromboembolic pulmonary hypertension"
- Charles Puelz (Baylor College of Medicine and Texas Children's Hospital, United States) "A fluid/structure interaction model of the human heart"
- Jae Lee (Johns Hopkins University, United States) "Fluid-structure interaction models of bioprosthetic heart valves to study leaflet kinematics"
- Zachary Sexton (Stanford University, United States) "Multiscale Hemodynamics of Autogenerated Cardiovascular Networks"
MS20-NEUR: Biological Rhythms and Motor Control
Organized by: Yangyang Wang (University of Iowa, USA), Peter Thomas (Case Western Reserve University, USA) Note: this minisymposia has multiple sessions. The second session is MS19-NEUR.
- Jon Rubin (University of Pittsburgh, USA) "Combining rhythm generation and pattern formation in a core respiratory neural circuit"
- Casey Diekman (New Jersey Institute of Technology, USA) "Oxygen handling and parameter space interrogation in a minimalist closed-loop model of the respiratory oscillator"
- Todd Young (Ohio University, USA) "An Altered Van der Pol Oscillator and Stomatogastric Ganglion"
- Yaroslav Molkov (Georgia State University, USA) "Control of steering in quadrupedal locomotion"
MS20-ONCO: Integrating quantitative imaging and mechanistic modeling to characterize tumor growth and therapeutic response
Organized by: Guillermo Lorenzo (University of Pavia, Italy), David Hormuth (The University of Texas at Austin, US), Angela Jarrett (The University of Texas at Austin, US), Thomas Yankeelov (The University of Texas at Austin, US) Note: this minisymposia has multiple sessions. The second session is MS14-ONCO.
- Darren Tyson (Vanderbilt University, US) "The many dimensions of anticancer drug response—quantifying cell population dynamics at single-cell resolution using automated live-cell microscopy"
- Victor Perez-Garcia (University of Castilla-La Mancha, Spain) "From metabolic imaging to biomarkers through mathematical models in cancer"
- Jana Lipkova (Brigham and Women’s Hospital, Harvard Medical School, US) "Personalized Radiotherapy Design for Glioblastoma:Integrating Mathematical Tumor Models,Multimodal Scans and Bayesian Inference"
- Guillermo Lorenzo (University of Pavia, Italy) "Personalized image-based modeling of organ-confined prostate cancer: exploring the mechanical interactions between tumor growth and coexisting benign prostatic hyperplasia"