ONCO-

# Differentiation and stemmness, in cell migration, cancer invasion, and development

**Organizers:**

#### Nikolaos Sfakianakis, Linnea C. Franssen

**Description**:

As the mathematical research of cancer is entering a mature stage, the efforts of the community focus on the transfer of information between the various relevant biological scales. With this in mind, we bring together researcher working in experimental and theoretical biology as well as mathematics in the aim to shed some light in mathematical approaches that are able to bridge the different scales. Central role in our minisymposium will play the presentation by Robert Insall —experimental and theoretical biologist working on cell migration— where he will be speaking about the most recent work in his lab in reverse chemotaxis. Subsequently Niklas Kolbe —mathematician working in epithelial-to- mesenchymal transition— will discuss an intracellular stochastic model describing of TGF-β signalling that they have developed in collaboration with the Institute of Molecular Biology in Mainz. In a higher scale, Cicely Macnamara— mathematician working on multiscale cancer invasion models— will discuss a hybrid atomistic-macroscopic coupling atomistic cancer cell migration with collective cancer cell invasion. In the higher scale, Filip Klawe —mathematician working on the macroscopic description of stem cells specification— will provide a mathematical framework for the study of evolving signal concentrations in evolving domains. It is expected that during this mini-symposium the participants (speakers and organisers) will establish a communication network between them and foster new research collaborations. It is moreover expected that it will draw the attention of the participants as it addresses several of the current difficulties in the mathematical study in cell differentiation and stemmness.

#### Luke Tweedy

*Beaton Institute of Cancer Research, Glasgow*

###### "Seeing around corners: Cell migration is determined by the complex interaction of environmental topology and attractant degradation"

#### Niklas Kolbe

*Faculty of Mathematics and Physics, Kanazawa University, Japan*

###### "Stochastic modelling of TGF-β signalling in single cells"

#### Cicely Macnamara

*School of Mathematics and Statistics, University of St. Andrews, UK*

###### "Computational modelling and simulation of cancer growth and migration within a 3D heterogeneous tissue"

#### Filip Klawe

*Institute of Applied Mathematics, Heidelberg University, Germany*