Accelerate Replication Fork velocity to kill cancer cells

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Ghanendra Singh

Indraprastha Institute of Information Technology Delhi
"Accelerate Replication Fork velocity to kill cancer cells"
Replication fork plays an important role during DNA replication. During DNA replication Fork movement rate increases during S phase in mammalian cells and also reduces during replication stress. There exists a molecular mechanism through which the replication fork adjusts their speeds during the S phase. In cancer cells, DNA replication is slower compared to normal cells and replication forks move slowly. So, this work proposes that if the replication fork speed can cross a particular threshold, the cancer cells won't be able to cope with the DNA replication and die in the process. A mechanistic mathematical model has been developed based on recent experimental findings. Mec1, Rad53 and Mrc1 are needed to create a positive feedback loop to stabilize replisome during stalled forks.

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