Mechanisms Underlying Cell Polarization and Its Role in Cell Development
Wednesday, June 16 at 07:45pm (PDT)Thursday, June 17 at 03:45am (BST)Thursday, June 17 11:45am (KST)
Weitao Chen (University of California, Riverside, United States), Michael Trogdon (Salk Institute for Biological Studies, United States), Roya Zandi (University of California, Riverside, United States)
Cell polarization is an important process in which some signaling molecule or cell component, originally distributed symmetrically, becomes locally concentrated as a result of symmetry breaking. Cell polarization is widely observed during cell division in many different cell types, such as yeast cells, neurons, epithelial cells etc.. Such a process is required for cell differentiation and morphological change to give rise to specialized functions. Although lots of studies have been conducted to understand the mechanism underlying cell polarization, it still remains unclear for many biological systems, such as the initiation signal of cell polarity, the role of mechanical components in symmetry breaking, decision on the cell polarization sites etc.. Different modeling approaches have been developed to understand different biological systems, especially those requiring challenging experiments and involving complex structural changes. The goal of this minisymposium is to provide an opportunity for researchers in this field to exchange ideas about mathematical models and approaches to incorporate biological data.